Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with …
S Lindberg, SH Pedersen, R Mogelvang… - American Heart …, 2012 - Elsevier
BACKGROUND: The complement system is an important mediator of inflammation, which
plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies
suggest that activation of the complement cascade resulting in the formation of soluble
membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture
and may be the direct cause of tissue damage related to ischemia/reperfusion injury.
However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to …
plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies
suggest that activation of the complement cascade resulting in the formation of soluble
membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture
and may be the direct cause of tissue damage related to ischemia/reperfusion injury.
However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to …
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